Several previous studies have shown that the expression of FLT3 is activated in acute promyelocytic leukemia (APL) and adult B lymphoblastic.
Pattern and prognostic value of FLT3-ITD mutations in Chinese de novo adult acute myeloid leukemia. Liu SB(1), Qiu QC(2)(3)(4), Bao.
Additionally, more recent evidence from a large study of the mutational landscape in adult AML identified FLT3 as one of the most commonly.
The ADMIRAL study is an open-label multicenter randomized phase 3 study for adults with relapsed and/or refractory AML with FLT3 mutations.
The frequency of FLT3-ITD is 24% in adult AML, 10% in pediatric AML and in nearly a third of cases of acute promyelocytic leukemia (APL). Perhaps because of.